NMN - NAD+ Booster
NMN - NAD+ Booster 1NMN - NAD+ Booster 2NMN - NAD+ Booster 3NMN - NAD+ Booster 4NMN - NAD+ Booster 5NMN - NAD+ Booster 6NMN - NAD+ Booster 7
How does this address the menopause energy crash? 🤔

During menopause, dropping estrogen triggers an enzyme (CD38) that consumes your NAD+ — the fuel your cells need for energy, focus, and repair. Perennial supplies NMN, the precursor your cells use to make NAD+, to support the system that's being drained. It's not another hormone supplement — it works on the system underneath.

How does the 60 day trial work? 🗓

Try Perennial daily and give it a fair shot. If you don't feel it's supporting your energy, clarity, or overall well-being the way you hoped, just email us within 60 days of your first delivery. We'll refund your first bottle — no hoops, no hard feelings.

How does the subscription work? 🔄

Delivered every 30 days (or every 90 with the bundle). Skip, pause, or cancel anytime in your account.

Is it worth subscribing? ✅

Subscribers save 33% forever, get free shipping, 2x rewards points, and never run out — cancel anytime.

★★★★★ Rated 4.6/5 from 461 Reviews

Fuel for Engine Two

Daily NMN for Menopause Energy — the engine nobody told you was stalling

  • Supports All-Day Energy
  • NMN — Studied in Human Trials
  • Cellular Repair & Recovery
  • 60-Day Money Back Guarantee

FREE Express Shipping · Ships in 24 hours

60-Day Money-Back Guarantee — keep the bottle.
NMN - NAD+ BoosterFuel for Engine Two
🔬 Third-Party Tested for Purity
📄 Backed by Research
🛡️ 60-Day Money-Back Guarantee
🚚 FREE Express Delivery

What Women Are Saying

Here's what women going through menopause report.

Rejuvenated Energy
Rejuvenated Energy
Clear Brain Fog
Clear Brain Fog
No 3PM Crash
No 3PM Crash

Backed by Research, Not Rented Experts

No gimmicks, no hype. Just the cellular science behind why menopause drains more than your hormones — and a formula built around a well-studied NAD+ precursor.

Feels like I finally got my mornings back. By week two, I noticed I wasn't dragging myself to the kitchen. I have more steady energy and I'm getting through my workday without that fogginess.
Laura P, 47
Perennial Member
Verified Buyer
★★★★★
I was ready to accept that this was just my life now. Two months in, I realized I hadn't napped in my car at lunch in weeks. I was making dinner and still had energy to talk to my husband. I genuinely didn't think that was possible anymore.
Jen R., 44
Perennial Member
Verified Buyer
★★★★★
It's subtle, but the good kind of subtle. Not a miracle pill. It just quietly supports you. More energy, clearer thinking, and I'm less worn-down at the end of the day.
Michelle L, 38
Perennial Member
Verified Buyer
★★★★★

Perennial is built on published studies, clinically studied ingredients, and transparent dosing. We show you exactly what's in each capsule — and why a woman going through menopause needs a well-studied NAD+ precursor, not the long way around. The underlying research: UCLA's PNAS study of 3,100 women, which found menopause accelerated biological aging by about 6% · Camacho-Pereira et al., Cell Metabolism (2016), identifying CD38 as the primary NAD+-consuming enzyme in aging · Massudi et al., PLOS ONE (2012), which found NAD+ falls roughly 50% between ages 40 and 60 · and preclinical work at the Buck Institute's Center for Healthy Aging in Women on rising CD38 activity in aging ovarian tissue. These studies describe the underlying biology; they are not clinical trials of this product.

Menopausal fatigue isn't a lack of motivation.It's a second system crashing.

Relative NAD+ Availability (Indexed to Age 20 = 100) 10080604020 20304050607080 Age NAD+ Availability (Index)
Illustrative trend for education (relative index, not a clinical measurement).

Your NAD+ levels collapse during menopause

NAD+ is the fuel your cells need for energy, focus, and repair. Your brain uses it to think clearly. Your muscles use it to get through the day. Without enough, nothing works — no matter how much sleep you get or how clean you eat.

Here's what menopause has to do with it. Estrogen helps keep an enzyme called CD38 in check. As estrogen falls, CD38 becomes more active — and CD38's job is to consume NAD+. So this isn't only the slow decline everyone gets with age. It's that decline, plus a second drain opening up at exactly the wrong time.

Standard bloodwork doesn't measure any of this. That's why it keeps coming back fine.

When NAD Runs Low:

  • The 2 PM wall — empty-tired, not sleepy-tired
  • Sitting in your car after work before walking inside
  • Reading the same email three times and not retaining it
  • Waking at 3 AM, lying there, unable to fall back asleep
Shop Now

But Here's The Good News…

Unlike hormones, NAD+ can be rebuilt. Your cells still have the machinery. They just need fuel.

Look at what's in your cabinet right now. The magnesium. The ashwagandha. The black cohosh. The B-complex you were sure would be the one.

None of that was wasted money or bad judgment. Every one of them was built for the first system — and inside that system, they did their job.

That's why hormone therapy could ease the hot flashes and leave the bone-deep tiredness exactly where it was. That's why the 2 PM crash never responded to more coffee. That's why you can sleep eight hours and still wake up feeling like you didn't. Different system.

You need support for Engine Two — the one nobody told you was stalling.

Perennial is NMN built for the menopausal NAD+ decline. One daily serving. 500 mg of the precursor your cells use to make NAD+ — no stimulants, no hormones, no fake energy.

Just clean, research-backed cellular fuel for the engine that's been running on empty.

It fits your routine with zero effort. It works quietly underneath everything else. With consistent use, women report feeling steadier, sharper, and more like themselves — the version they thought was gone.

Both engines fueled. That's the Perennial difference.

Try Perennial Now
NMN capsules

The NAD+ Precursor

You can't just swallow NAD+.

It's too fragile to survive digestion. So the real question is how you raise it — and most methods fall short.

NAD+ pills Too large to absorb — mostly broken down in digestion.
NAD+ IV drips Somewhat effective — but needles, clinic visits, and $200+ a session.
NR supplements A real NAD+ precursor, with its own human research.
NMN (Perennial) The precursor studied in postmenopausal women. Verified 500 mg.
NMN powder

500mg NMN

The clinical dose used in NMN research

NR→ NMN→ NAD+

NMN is the precursor used in the leading human NAD+ trials.

One active ingredient, transparently dosed — no proprietary blends, nothing hidden. Just a well-studied way to rebuild the fuel your cells are losing.

2 veggie capsules60 count · 30-day supplyNon-GMO · Gluten-freeMade in USA

🔬 Third-party tested (ISO 17025): 533 mg NMN verified per serving — heavy metals & microbials all clean.

Shop Now

What Women Actually Feel

What women actually feel when Engine Two gets fuel again

This isn't a stimulant. It's not an overnight miracle. Here's what women going through menopause typically report.

Day 1: Your Cells Start Rebuilding

Day 1: Your Cells Start Rebuilding

No jolt. No stimulant buzz. Your cells begin absorbing NMN and producing new NAD+. Sleep may shift first — falling asleep easier, fewer 3 AM wake-ups. Change starts quietly.

Month 1: The 2 PM Wall Softens

Month 1: The 2 PM Wall Softens

The afternoon wall softens. You finish your workday without needing to collapse. You notice you're not reaching for coffee at 2 PM. Brain fog lifts enough that you can follow a conversation without losing the thread.

Month 3+: A New Baseline

Month 3+: A New Baseline

You feel more like yourself than you have in years. Words come easier. The fog is gone — not managed, gone. You stop thinking about menopause as something happening to you and start living past it. Both engines running.

Try Perennial Now

What sets Perennial's NMN apart from ordinary supplements?

NMN that targets the cellular system — not just the hormonal one.

  • Convenience: one daily serving, 500 mg NMN.
  • Transparency: 100% open label; no hidden blends.
  • Vitality: built around menopausal NAD+ decline specifically.
  • Science: ingredients backed by published research.
  • Potency: 533 mg verified per serving, third-party tested.
Perennial NMNNR BrandsOrdinary Supplements
Studied NAD+ precursor ✓ ✗ ✗
Clinical 500 mg dose ✓ ~ ✗
Third-party purity tested ✓ ~ ✗
Single ingredient, no fillers ✓ ✓ ✗
60-day money-back guarantee ✓ ✗ ✗
Built for women in menopause ✓ ✗ ✗
Shop Now
60 DAYRisk FreeTrial

Cellular Support for Women Going Through Menopause

The enzyme doesn't take weekends off. Neither should your cellular support. Subscribe and never run out — members save up to 56% plus free express shipping, and can skip, pause, or cancel anytime.

Try Perennial Now
Perennial customer

Questions, answered

What is NAD+ and why is it important?

NAD+ is a coenzyme your cells use to turn nutrients into usable energy and support repair pathways. It naturally declines with age — supporting your body's NAD+ production helps maintain energy, focus, and recovery.

Is this specifically for women in menopause?

Perennial supports NAD+ levels in anyone over 35. But it's especially relevant for women going through perimenopause and menopause, because of how estrogen decline accelerates NAD+ loss: the enzyme CD38, which consumes NAD+, becomes more active when estrogen drops. Perennial supplies NMN — the precursor your cells use to make NAD+ — to support the system that decline is draining.

Perimenopause, menopause, or postmenopause — does it matter which stage I'm in?

No — it's relevant across all three. The NAD+ drain starts in perimenopause, when estrogen first begins fluctuating (often in your early-to-mid forties, before periods become irregular). It continues through menopause and into the postmenopausal years, when estrogen settles at a permanently lower level and stays there.

So whether you're just starting to feel the changes or you're years past your last period, the cellular energy decline is still in play. There's no stage where this stops being relevant — only how much ground there is to make up.

How and when should I take it?

Take 2 veggie capsules once daily, ideally 20–30 minutes before a meal. Consistency matters more than exact timing.

How long before I notice a difference?

Most women report sleep improvements within the first 1–2 weeks. The afternoon energy wall typically softens around week 3–4. By month 2–3, the compounding effect is clear — steadier energy, sharper focus, and a feeling that you're actually present again.

That's why our guarantee is 60 days, not 30.

How does the 60-day guarantee work?

Try Perennial for 60 days. If you don't feel a difference, email us within 60 days of your first delivery for a full refund of your first bottle — and keep the bottle.

Can I take this alongside HRT or my other supplements?

Perennial works on a different system than hormone therapy, and many customers take both. That said, we're not your doctor — if you're pregnant, nursing, taking medication, or managing a health condition, check with yours before starting anything new.

What is the difference between NR and NMN?

NR (nicotinamide riboside) and NMN are both NAD+ precursors, and both have their own human research. We use NMN because it's the form studied in the leading NAD+ trials — including a 2021 Science study in postmenopausal women — at a transparent, verified 500 mg dose.

Where is this product manufactured?

Made in the USA (Live Perennial Corp, Amherst NY) in a facility following cGMP standards, and third-party tested for purity.