Aging isn’t just about time.
It’s about biology.
For decades, we accepted fatigue and brain fog as "normal" parts of getting older. The science says otherwise.
Your body is made of 37 trillion cells. When you feel "old", tired, foggy, slow to recover, it is not a moral failing. It is a cellular power failure. Perennial was engineered to turn the lights back on.
The "NAD+ Cliff"
By age 40, your NAD+ levels drop by 50%.
NAD+ is the fuel your cells use to create energy. Without it, your mitochondria (the power plants of your cells) wither.
At 20
Your cells are burning bright. You recover fast. You sleep deep.
At 30
The "invisible decline" begins. The surplus is gone. Recovery takes a little longer. You sleep, but you don't feel rested.
At 40+
The fuel line is cut. This leads to the "Invisible Decline": Brain fog, afternoon fatigue, and poor recovery.
Your NAD levels declines with age
NAD+ is a coenzyme your cells use to turn nutrients into usable energy and support key repair pathways.
Across aging research, NAD+ tends to decline over time, especially under modern stressors like poor sleep, overtraining, and chronic stress.
When NAD Runs Low:
Less all-day energy (bigger afternoon crash)
Slower recovery and feeling more “run down”"
Lower mental clarity and focus
Sleep that feels less restorative
Why boosting NAD+
isn't enough.
Most longevity supplements make a critical mistake: They try to fill a leaky bucket. Adding NAD+ (via Nicotinamide Riboside) is essential, but if your cells are inflamed or under oxidative stress, that energy leaks out immediately.
We don't just pour more fuel into the tank. We seal the tank, clean the engine, and then hit the gas.
Refuel
Boost NAD+ levels
Defend
Neutralize the toxins that kill your cells
Activate
Switch on your body's "longevity genes" (Sirtuins)
The Core Four
4 clinically-aligned ingredients to restore NAD+, activate longevity genes, and fuel sustained energy.
Nicotinamide Riboside (NR) is a high-efficiency precursor that your cells use to create NAD+, the essential fuel for mitochondrial energy. We use a clinical-strength 500 mg dose to directly reverse the age-related decline of this vital molecule.
Trans-Resveratrol (150 mg)
The Activator
If NAD+ is the fuel, Resveratrol is the gas pedal. It activates Sirtuins (longevity genes) that repair DNA and regulate aging. We use Trans-Resveratrol—the bioactive form—to ensure it can effectively "turn on" these cellular repair pathways.
Quercetin (100 mg)
The Multiplier
A dual-action defender. Quercetin inhibits CD38 (an enzyme that destroys NAD+), plugging the leak in your energy tank. It also inhibits the enzymes that break down Resveratrol, significantly boosting its absorption and effectiveness in the body.
Galactomannans (10 mg)
The Balancer
A stealthy stabilizer. Galactomannans are gel-forming fibers that slow sugar absorption and smooth post-meal energy swings. Potent even at small doses, they also nourish your gut microbiome—supporting metabolic balance and steady energy from the inside out.
What sets Perennial’s NAD 4-in-1 apart from ordinary supplements?
A 4-in-1 formulation crafted for convenience, consistency, and daily longevity support
Convenience: 5 ingredients in 1, perfect formulation.
Transparency: 100% open label; no hidden blends.
Vitality: Supports cellular energy & healthy aging.
Science: Ingredients backed by published research.
Defense: Added antioxidants for cellular protection
Potency: Clinically dosed for real results.
NAD+
5-in-1
Generic
Supplements
Age Gracefully. Start Living.
The first step to your new biological age starts here.
Meet the athletes