4.7 511 reviews

🛡 60-Day Money-Back Guarantee · Third-Party Tested

Daily NMN · NAD+ Support

Energy That Carries You Through the Day

Perennial replenishes NAD+, the molecule your cells use to make it.

Cellular Energy
Mental Clarity
Healthy Aging
Metabolism Support
Faster Recovery
Cellular Repair

83% of this batch claimed

Subscribe & Save

🚚 FREE Express Shipping$12 valueINCLUDED

💰 10% Cash Backon every orderINCLUDED

🛡 60-Day Risk-Freekeep the bottleINCLUDED

60-Day Guarantee Refills every 30 days Cancel anytime

Will I actually notice anything, and when? ⏳

Give it a few weeks. In the human trials, NAD+ in the blood rose within that time. What you feel varies, and some people notice little early on. If it isn't doing anything for you, email us within 60 days of your first delivery for a refund. You're covered either way.

Why NMN, and why Perennial's? 🧬

NMN is what your body uses to make NAD+, the molecule your cells use to turn food into energy. Ours is that one ingredient, 500 mg a day, inside the range the human trials used, nothing else in the capsule. An independent lab tests every batch, and it's made and shipped in the USA.

What's in it, and how do I take it? 🧪

500 mg of NMN per serving, nothing else in the capsule. Take two veggie capsules together once a day, ideally in the morning, with or without food. Each bottle is 60 capsules, a 30-day supply. An independent lab checks every batch: the NMN matches the label, and nothing that shouldn't be there is.

Is it safe? Can I take it with my medication? 💊

NMN is generally well tolerated. On medication, pregnant or nursing, or managing a health condition? Please check with your doctor before you start. A quick call is worth it.

Shipping & returns 📦

Made and shipped in the USA. Your order leaves within 24 hours, and the date above the button is for an order placed today. Subscriptions ship express, free. US only for now. Returns are easy: nothing to send back on a single bottle; on the 3-pack, the two unused bottles come back to us. Email help@liveperennial.co.

How does the 60 day trial work? 🗓

Simple. Take it daily. Our 60-day guarantee covers one bottle: if it isn't helping, email help@liveperennial.co within 60 days of your first delivery and we refund it. You keep the bottle. Bought the 3-pack? Send the two unused bottles back and we refund your order. No hoops, no hard feelings.

Energy That Carries You Through the Day

🇺🇸 Made & Shipped in the USA

🧬 Single Ingredient, Open Label

🔬 ISO 17025 Lab Tested

🗓 Skip, Pause or Cancel Anytime

Customer Testimonials

Customers on what changed, in their own words.

In their own words

Feels like I finally got my mornings back. By week two, I noticed I wasn't dragging myself to the kitchen. I have more steady energy and I'm getting through my workday without that fogginess.

Laura P, 47

Perennial Member

Verified Buyer

★★★★★

My new non-negotiable morning ritual. I've tried other longevity supplements and never stuck with them. Perennial is the first one that delivered enough for me to feel it.

Mark S, 56

Perennial Member

Verified Buyer

★★★★★

It's subtle, but the good kind of subtle. Not a miracle pill. It just quietly supports you. More energy, clearer thinking, and I'm less worn-down at the end of the day.

Michelle L, 38

Perennial Member

Verified Buyer

★★★★★

One Ingredient. Four Payoffs.

Real Benefits. Backed by Research.

One molecule. One daily serving. Decades of NAD+ research behind every serving.

EnergySteady, not spiked.

NAD+ powers the mitochondria that turn food into usable energy. Daily NMN keeps the supply topped up — steady output through the day instead of caffeine spikes and afternoon crashes.

ClarityFocused, not foggy.

Your brain is one of the most energy-hungry organs you own. When NAD+ is replenished, focus holds longer and words come easier — less of that mid-sentence blank.

RecoveryBounce back faster.

NAD+ fuels your body’s natural repair and cleanup crews. With daily NMN, recovery after activity feels quicker and everyday stress sits lighter.

Healthy AgingSupport what slows down.

NAD+ falls roughly by half between your 40s and 60s — and cellular energy, repair, and metabolism slow with it. One 500 mg serving a day replenishes the molecule those systems run on.

Midlife fatigue isn't a lack of motivation.It's biology.

Illustrative curve of the published age-related decline in NAD+ (Massudi 2012). Indexed to age 20 = 100.

The gap40s → 60sNAD+ falls by roughly half

NAD+ is a coenzyme your cells use to turn nutrients into usable energy and to run their repair pathways.

Across aging research it declines steadily with age, and the decline runs faster under poor sleep, overtraining and chronic stress. The cells that use the most of it, brain cells among them, feel the shortfall first.

When NAD Runs Low:

Less all-day energy (bigger afternoon crash)
Slower recovery and feeling more "run down"
Lower mental clarity and focus

Shop Now

The research

Backed by Research, Not Rented Experts

30+human NMN studies

10yrsof human NMN trials, since Keio University's first in 2016

500mgper serving, a clinical-trial dose

1

NAD+ falls with age.

NAD+ drops steeply between about 40 and 60.

StudiesMassudi, PLOS ONE 2012Zhu, PNAS 2015

2

NMN raises NAD+.

Two weeks of daily NMN roughly doubled blood NAD+ against placebo.

StudiesChristen, Nature Metabolism 2026Zhang, 12-trial meta-analysis 2025

3

Cells use NAD+ to make energy.

NAD+ is the molecule cells use to turn food into energy.

StudiesCantó, Cell Metabolism 2015Covarrubias, Nature Reviews MCB 2021

Read all the studies

Human RCT Two weeks of 1,000 mg a day roughly doubled blood NAD+ versus placebo.Christen et al., Nature Metabolism 2026 · 65 adults · 14 days · three NAD+ precursors comparedRead ↗

Human RCT Blood NAD+ rose with the dose over 60 days at 300, 600 and 900 mg a day, and leveled off around 600 mg.Yi et al., GeroScience 2022 · 80 healthy adults · 60 days · manufacturer-fundedRead ↗

Human RCT 250 mg a day for 12 weeks raised blood NAD+ in healthy adults, with no serious adverse events reported.Okabe et al., Frontiers in Nutrition 2022 · 30 adults · 250 mg/day · 12 weeksRead ↗

Human RCT Ten weeks of NMN improved how muscle responds to insulin by about 25%, versus placebo.Yoshino et al., Science 2021 · 25 adults · 250 mg/day · 10 weeks · NIH-funded, investigator-led · one endpoint, not yet replicatedRead ↗

Human RCT Twelve weeks of 250 mg raised blood NAD+ in older men. The effect on grip strength was small.Igarashi et al., npj Aging 2022 · 42 men aged 65+ · 250 mg/day · 12 weeksRead ↗

Review Across twelve human trials pooled together, oral NMN raised blood NAD+.Zhang et al., Critical Reviews in Food Science and Nutrition 2025 · Meta-analysis · 12 trials · 513 participantsRead ↗

Human study NAD+ in human tissue was markedly lower in older adults than in young adults.Massudi et al., PLoS ONE 2012 · Skin samples, ages 0 to 77Read ↗

Human study In living human brain, NAD+ measured lower with age.Zhu et al., PNAS 2015 · In-vivo magnetic resonance measurementRead ↗

Human study The first human NMN trial: single doses up to 500 mg were well tolerated.Irie et al., Endocrine Journal 2020 · 10 healthy men · 100, 250 and 500 mg single doses · Keio UniversityRead ↗

Review NAD+ sits at the centre of how cells convert nutrients into usable energy.Cantó et al., Cell Metabolism 2015 · Review of NAD+ metabolism and energy homeostasisRead ↗

Review NAD+ metabolism and its roles in cellular processes during ageing.Covarrubias et al., Nature Reviews Molecular Cell Biology 2021 · Master reviewRead ↗

Animal study In old mice, restoring NAD+ with NMN reversed age-related decline in blood-vessel function. A mouse result, not a human one.Das et al., Cell 2018 · Aged mice · NMN in drinking waterRead ↗

Animal study In aged mice, raising NAD+ restored the signalling between the nucleus and mitochondria that fails with age. A mouse result, not a human one.Gomes et al., Cell 2013 · Aged mice · NMN injectionRead ↗

What to expect

Your first 90 days

NMN is a daily supplement, not a quick fix. In the trials, blood NAD+ rises within weeks. What that feels like builds more slowly, and people who stick with it tend to describe it like this.*

Start the first 30 days

*Individual experiences vary. These are patterns customers describe, not guaranteed results. 60-day money-back guarantee.

Weeks 1 to 2: Nothing dramatic

Two capsules with the morning coffee. That is the whole routine.
In the trials, blood NAD+ rose within weeks. Nobody feels that part.*
Most people report nothing yet. That is normal.

Month 1: The first small tells

The mid-afternoon dip tends to soften first.*
Some notice they get through the day with less to push against.*
Others notice nothing until month two, still inside the 60-day window.

Months 2 to 3: It compounds

Steadier energy across the day, without a stimulant.*
Focus that holds a little longer.*
Recovery after activity that feels quicker.*

Month 3 and on: The new normal

Most people say they stop noticing it, until they miss a week.*
A gap between bottles is usually when the difference shows.*
Two capsules, once a day. Still the whole routine.

What sets Perennial's NMN apart from ordinary supplements?

A formulation crafted for convenience, consistency, and daily longevity support.

	Perennial NMN	NR Brands	Ordinary Supplements
Studied NAD+ precursor	✓	✓	✗
500 mg per serving, in the studied range	✓	~	✗
Third-party purity tested	✓	~	✗
Single ingredient, no fillers	✓	✓	✗
60-day money-back guarantee	✓	✗	✗

Shop Now

Questions, answered

View all FAQs ›

What is NAD+ and why does it matter?

NAD+ is a coenzyme every cell uses to turn food into usable energy and to run its repair pathways. Levels fall with age. Supporting the body's own NAD+ production is what NMN is for: it is the precursor cells use to make it.

How and when should I take it?

Two veggie capsules once a day, taken together, ideally in the morning. With or without food. Consistency matters more than timing.

How long until I notice anything?

Give it the full 60 days of the guarantee, taken daily. Many people describe a steadier afternoon within the first few weeks, and the effect builds with consistent use. Nothing about NMN is a jolt, so the change tends to show up as an absence: the wall that used to arrive at three doesn't.

Is it third-party tested?

Yes. Each batch is tested by an independent ISO 17025 accredited lab for identity, potency, heavy metals and microbials. The most recent certificate measured 533 mg of NMN per serving against the 500 mg on the label, with heavy metals and microbials all passing.

Can I take it with coffee, or while fasting?

Yes to both. NMN has no known interaction with caffeine, and two veggie capsules carry practically no calories, so it fits inside a fasting window.

Is it safe? Any side effects?

NMN has been generally well tolerated across the human trials published to date. Some people report mild stomach upset or a headache in the first few days that settles on its own or with food. Anyone taking medication, pregnant or nursing, or managing a health condition should check with their doctor before starting.

What is the difference between NR and NMN?

Both are NAD+ precursors, and both have their own human research. We use NMN because it is the form studied in the leading independent human trial, a 2021 randomized, placebo-controlled study published in Science, at a transparent, verified 500 mg dose.

Where is it made?

Made and shipped in the USA, in a facility following cGMP standards, and third-party tested for purity.

What happens at renewal, and can I change the date?

We email you three days before each renewal. Your next renewal date is shown in your account, and you can move it, skip a delivery, pause, or cancel there at any time before it processes. Your subscriber price stays the same for as long as you stay subscribed.

How does the 10% cash back work?

10% of every subscription order comes back to you as store credit, ready to use on your next order. It shows in your account.

Do you ship outside the United States?

Not yet. We ship within the US only, with free express shipping on every subscription order.

60 DAYRisk FreeTrial

NAD+ Support for Clean, Steady Energy

60 days. Not for you? Your first order is refunded and you keep the bottle.

Try Perennial Now

Stock Up. Save More.

Make NAD+ part of your daily routine — risk-free for 60 days.

83% of this batch claimed

Subscribe & Save

🚚 FREE Express Shipping$12 valueINCLUDED

💰 10% Cash Backon every orderINCLUDED

🛡 60-Day Risk-Freekeep the bottleINCLUDED

60-Day Guarantee Refills every 30 days Cancel anytime

Energy That Carries You Through the Day

How subscriptions work

Customers on what changed, in their own words.

In their own words

Real Benefits. Backed by Research.

Midlife fatigue isn't a lack of motivation.It's biology.

Backed by Research, Not Rented Experts

NAD+ falls with age.

NMN raises NAD+.

Cells use NAD+ to make energy.

Your first 90 days

Weeks 1 to 2: Nothing dramatic

Month 1: The first small tells

Months 2 to 3: It compounds

Month 3 and on: The new normal

What sets Perennial's NMN apart from ordinary supplements?

Customer Reviews

Questions, answered

NAD+ Support for Clean, Steady Energy

Stock Up. Save More.

How subscriptions work