4.7 511 reviews

🛡 60-Day Money-Back Guarantee · Third-Party Tested

Daily NMN · Brain Fog

Less Brain Fog, More of Your Old Self

Your brain is 2% of you and burns about 20% of your energy. Perennial replenishes NAD+, the molecule it runs on.

Mental Clarity
Brain Energy
Focus Support
Cellular Repair
Healthy Aging
Faster Recovery

83% of this batch claimed

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Will I actually notice anything, and when? ⏳

Give it a few weeks. In the human trials, NAD+ in the blood rose within that time. What you feel varies, and some people notice little early on. If it isn't doing anything for you, email us within 60 days of your first delivery for a refund. You're covered either way.

How is this different from lion's mane, ginkgo or another coffee? 🧠

Those work on the brain directly, or assume it needs more practice. Perennial works a layer underneath, on cellular energy. Your brain is about 2% of your weight and burns close to 20% of your energy. That energy runs on NAD+, which falls with age. Perennial supplies 500 mg of NMN, the precursor your cells use to make it. Not a nootropic, not a stimulant.

What's in it, and how do I take it? 🧪

500 mg of NMN per serving, nothing else in the capsule. Take two veggie capsules together once a day, ideally in the morning, with or without food. Each bottle is 60 capsules, a 30-day supply. An independent lab checks every batch: the NMN matches the label, and nothing that shouldn't be there is.

Is it safe? Can I take it with my medication? 💊

NMN is generally well tolerated. On medication, pregnant or nursing, or managing a health condition? Please check with your doctor before you start. A quick call is worth it.

Shipping & returns 📦

Made and shipped in the USA. Your order leaves within 24 hours, and the date above the button is for an order placed today. Subscriptions ship express, free. US only for now. Returns are easy: nothing to send back on a single bottle; on the 3-pack, the two unused bottles come back to us. Email help@liveperennial.co.

How does the 60 day trial work? 🗓

Simple. Take it daily. Our 60-day guarantee covers one bottle: if it isn't helping, email help@liveperennial.co within 60 days of your first delivery and we refund it. You keep the bottle. Bought the 3-pack? Send the two unused bottles back and we refund your order. No hoops, no hard feelings.

Less Brain Fog, More of Your Old Self

🇺🇸 Made & Shipped in the USA

🧬 Single Ingredient, Open Label

🔬 ISO 17025 Lab Tested

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Customer Testimonials

The symptom nobody brings to the appointment.

In their own words

Feels like I finally got my mornings back. By week two, I noticed I wasn't dragging myself to the kitchen. I have more steady energy and I'm getting through my workday without that fogginess.

Laura P, 47

Perennial Member

Verified Buyer

★★★★★

My new non-negotiable morning ritual. I've tried other longevity supplements and never stuck with them. Perennial is the first one that delivered enough for me to feel it.

Mark S, 56

Perennial Member

Verified Buyer

★★★★★

It's subtle, but the good kind of subtle. Not a miracle pill. It just quietly supports you. More energy, clearer thinking, and I'm less worn-down at the end of the day.

Michelle L, 38

Perennial Member

Verified Buyer

★★★★★

One Ingredient. Four Payoffs.

Real Benefits. Backed by Research.

One molecule. One daily serving. Decades of NAD+ research behind every serving.

ClarityFocused, not foggy.

Your brain is one of the most energy-hungry organs you own. When NAD+ is replenished, focus holds longer and words come easier — less of that mid-sentence blank.

EnergySteady, not spiked.

NAD+ powers the mitochondria that turn food into usable energy. Daily NMN keeps the supply topped up — steady output through the day instead of caffeine spikes and afternoon crashes.

RecoveryBounce back faster.

NAD+ fuels your body’s natural repair and cleanup crews. With daily NMN, recovery after activity feels quicker and everyday stress sits lighter.

Healthy AgingSupport what slows down.

NAD+ falls roughly by half between your 40s and 60s — and cellular energy, repair, and metabolism slow with it. One 500 mg serving a day replenishes the molecule those systems run on.

You're not forgetting more.You're paying more to remember.

Illustrative curve of the published age-related decline in NAD+ (Massudi 2012). Indexed to age 20 = 100.

The gap40s → 60sNAD+ falls by roughly half

Thinking is the most expensive thing your body does

You write the name down before the call. You keep a list on your phone that lived in your head five years ago. From the outside, you look organized. You haven't lost the capability. You're paying more for it.

Your brain is the most expensive tissue you own. It runs on NAD+, and NAD+ falls with age. When fuel gets tight, the tissue with the highest running costs feels it first.

A standard blood panel has no line for cellular fuel. That's how your labs come back fine while you feel like this.

What people describe when they say “fog”:

The word is right there, and it doesn't come
Blanking on a name mid-introduction
Reading the same paragraph again
Walking into a room and forgetting why

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The research

Backed by Research, Not Rented Experts

30+human NMN studies

10yrsof human NMN trials, since Keio University's first in 2016

500mgper serving, a clinical-trial dose

1

NAD+ in the brain falls with age.

In living human brain, NAD+ measured lower with age.

StudiesZhu, PNAS 2015Massudi, PLOS ONE 2012

2

NMN raises NAD+.

Two weeks of daily NMN roughly doubled blood NAD+ against placebo.

StudiesChristen, Nature Metabolism 2026Zhang, 12-trial meta-analysis 2025

3

Your brain runs on NAD+.

The brain is 2% of your weight and uses about 20% of your energy. NAD+ is how its cells make it.

StudiesRaichle, PNAS 2002Cantó, Cell Metabolism 2015

Read all the studies

Human study In living human brain, NAD+ measured lower with age.Zhu et al., PNAS 2015 · In-vivo magnetic resonance measurementRead ↗

Review The adult brain is about 2% of body weight and accounts for roughly 20% of the body's energy use.Raichle & Gusnard, PNAS 2002 · Review of the brain's energy budgetRead ↗

Human RCT Two weeks of 1,000 mg a day roughly doubled blood NAD+ versus placebo.Christen et al., Nature Metabolism 2026 · 65 adults · 14 days · three NAD+ precursors comparedRead ↗

Human RCT Blood NAD+ rose with the dose over 60 days at 300, 600 and 900 mg a day, and leveled off around 600 mg.Yi et al., GeroScience 2022 · 80 healthy adults · 60 days · manufacturer-fundedRead ↗

Human RCT 250 mg a day for 12 weeks raised blood NAD+ in healthy adults, with no serious adverse events reported.Okabe et al., Frontiers in Nutrition 2022 · 30 adults · 250 mg/day · 12 weeksRead ↗

Human RCT Ten weeks of NMN improved how muscle responds to insulin by about 25%, versus placebo.Yoshino et al., Science 2021 · 25 adults · 250 mg/day · 10 weeks · NIH-funded, investigator-led · one endpoint, not yet replicatedRead ↗

Human RCT Twelve weeks of 250 mg raised blood NAD+ in older men. The effect on grip strength was small.Igarashi et al., npj Aging 2022 · 42 men aged 65+ · 250 mg/day · 12 weeksRead ↗

Review Across twelve human trials pooled together, oral NMN raised blood NAD+.Zhang et al., Critical Reviews in Food Science and Nutrition 2025 · Meta-analysis · 12 trials · 513 participantsRead ↗

Human study NAD+ in human tissue was markedly lower in older adults than in young adults.Massudi et al., PLoS ONE 2012 · Skin samples, ages 0 to 77Read ↗

Human study The first human NMN trial: single doses up to 500 mg were well tolerated.Irie et al., Endocrine Journal 2020 · 10 healthy men · 100, 250 and 500 mg single doses · Keio UniversityRead ↗

Review NAD+ sits at the centre of how cells convert nutrients into usable energy.Cantó et al., Cell Metabolism 2015 · Review of NAD+ metabolism and energy homeostasisRead ↗

Review NAD+ metabolism and its roles in cellular processes during ageing.Covarrubias et al., Nature Reviews Molecular Cell Biology 2021 · Master reviewRead ↗

Animal study In old mice, restoring NAD+ with NMN reversed age-related decline in blood-vessel function. A mouse result, not a human one.Das et al., Cell 2018 · Aged mice · NMN in drinking waterRead ↗

Animal study In aged mice, raising NAD+ restored the signalling between the nucleus and mitochondria that fails with age. A mouse result, not a human one.Gomes et al., Cell 2013 · Aged mice · NMN injectionRead ↗

What to expect

Your first 90 days

NMN is a daily supplement, not a quick fix. In the trials, blood NAD+ rises within weeks. What that feels like builds more slowly, and people who stick with it tend to describe it like this.*

Start the first 30 days

*Individual experiences vary. These are patterns customers describe, not guaranteed results. 60-day money-back guarantee.

Weeks 1 to 2: Nothing dramatic

Two capsules with the morning coffee. That is the whole routine.
In the trials, blood NAD+ rose within weeks. Nobody feels that part.*
Most people report nothing yet. That is normal.

Month 1: The first small tells

The first tells are small: a meeting followed without losing the thread.*
Reading a page once, instead of twice.*
Others notice nothing until month two, still inside the 60-day window.

Months 2 to 3: The quiet one

People describe the name arriving without the detour.*
The list on the phone gets shorter.*
Steadier energy across the day, without a stimulant.*

Month 3 and on: The new normal

Most people say they stop noticing it, until they miss a week and the fog is back.*
That is usually when someone else notices too.*
Two capsules, once a day. Still the whole routine.

What sets Perennial's NMN apart from ordinary supplements?

Most of what you've tried works on the brain directly, or assumes it needs more practice. This works on the fuel underneath.

	Perennial NMN	NR Brands	Ordinary Supplements
Studied NAD+ precursor	✓	✓	✗
500 mg per serving, in the studied range	✓	~	✗
Third-party purity tested	✓	~	✗
Single ingredient, no fillers	✓	✓	✗
60-day money-back guarantee	✓	✗	✗

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Questions, answered

View all FAQs ›

What is NAD+ and why does it matter?

NAD+ is a coenzyme every cell uses to turn food into usable energy and to run its repair pathways. Levels fall with age. Supporting the body's own NAD+ production is what NMN is for: it is the precursor cells use to make it.

How and when should I take it?

Two veggie capsules once a day, taken together, ideally in the morning. With or without food. Consistency matters more than timing.

How long until I notice anything?

Give it the full 60 days of the guarantee, taken daily. Many people describe the first small tells within a few weeks, a meeting followed without losing the thread, and it builds with consistent use. Nothing about NMN is a jolt, so what people describe tends to show up as an absence: the detour to find the word gets shorter.

Is it third-party tested?

Yes. Each batch is tested by an independent ISO 17025 accredited lab for identity, potency, heavy metals and microbials. The most recent certificate confirmed the NMN per serving matches the label, with heavy metals and microbials all passing.

Can I take it with coffee, or while fasting?

Yes to both. NMN has no known interaction with caffeine, and two veggie capsules carry practically no calories, so it fits inside a fasting window.

Is it safe? Any side effects?

NMN has been generally well tolerated across the human trials published to date. Some people report mild stomach upset or a headache in the first few days that settles on its own or with food. Anyone taking medication, pregnant or nursing, or managing a health condition should check with their doctor before starting.

What is the difference between NR and NMN?

Both are NAD+ precursors, and both have their own human research. We use NMN because it is the form studied in the leading independent human trial, a 2021 randomized, placebo-controlled study published in Science, at a transparent, verified 500 mg dose.

Where is it made?

Made and shipped in the USA, in a facility following cGMP standards, and third-party tested for purity.

What happens at renewal, and can I change the date?

We email you three days before each renewal. Your next renewal date is shown in your account, and you can move it, skip a delivery, pause, or cancel there at any time before it processes. Your subscriber price stays the same for as long as you stay subscribed.

How does the 10% cash back work?

10% of every subscription order comes back to you as store credit, ready to use on your next order. It shows in your account.

Do you ship outside the United States?

Not yet. We ship within the US only, with free express shipping on every subscription order.

60 DAYRisk FreeTrial

Sixty Days to Decide.

60 days. Not for you? Your first order is refunded and you keep the bottle.

Try Perennial Now

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Make NAD+ part of your daily routine — risk-free for 60 days.

83% of this batch claimed

Subscribe & Save

🚚 FREE Express Shipping$12 valueINCLUDED

💰 10% Cash Backon every orderINCLUDED

🛡 60-Day Risk-Freekeep the bottleINCLUDED

60-Day Guarantee Refills every 30 days Cancel anytime

Less Brain Fog, More of Your Old Self

How subscriptions work

The symptom nobody brings to the appointment.

In their own words

Real Benefits. Backed by Research.

You're not forgetting more.You're paying more to remember.

Backed by Research, Not Rented Experts

NAD+ in the brain falls with age.

NMN raises NAD+.

Your brain runs on NAD+.

Your first 90 days

Weeks 1 to 2: Nothing dramatic

Month 1: The first small tells

Months 2 to 3: The quiet one

Month 3 and on: The new normal

What sets Perennial's NMN apart from ordinary supplements?

Customer Reviews

Questions, answered

Sixty Days to Decide.

Stock Up. Save More.

How subscriptions work