How does this address the menopause energy crash? 🤔
During menopause, dropping estrogen triggers an enzyme (CD38) that consumes your NAD+ — the fuel your cells need for energy, focus, and repair. Perennial's four ingredients address each stage of this cascade: NR produces new NAD+, Quercetin blocks the enzyme draining it, Resveratrol activates your repair pathways, and Galactomannans ensure absorption. It's not another hormone supplement — it works on the system underneath.
How does the 60 day trial work? 🗓
Try Perennial daily and give it a fair shot. If you don’t feel it’s supporting your energy, clarity, or overall well-being the way you hoped, just email us within 60 days of your first delivery.
We’ll refund you on your first bottle, no hoops, no hard feelings.
How does the subscription work? 🔄
We strive to make sure you have the best subscription experience possible. This means you have complete flexibility on when you want to cancel, skip, change your order date and pause upcoming orders.
In addition, we know life can get busy so we will always send you a reminder 3 days before your next order.
Choose “Subscribe & Save” at checkout and we’ll automatically send a new bottle at every month or 3 bottles every 90 days based on the interval you selected, so you never miss a day of NAD⁺ support.
Is it worth subscribing? ✅
Consistent daily use is where the real benefits happen. Healthy NAD⁺ levels build over time, and your cells rely on steady support to maintain energy, clarity, and overall vitality. Subscribing makes it effortless to stay on track.
You get a lower price, priority on new batches, earn 10% cashback points and enjoy the flexibility to pause, skip, or cancel anytime from your account.
Rated 4.6/5 from 323 Reviews
Get Your Energy Back
No Jitters. No Crash.
Just Clean Balance
Clinically backed support to help you feel steady, sharp, and energized again.
Made with five proven ingredients that work with your body, not against it.
Core Four
The Cellular Energy Formula
Built for Menopause
Restores All-Day Energy
Blocks the Enzyme Draining Your NAD+
Cellular Repair & Recovery
60-Day Money Back Guarantee
1 Pack
(30 day serving)
$0.42
/serving
Most popular!
3 for 2
(90 day serving)
$0.42
/serving
6 Pack
(180 Strips)
$0.42
/serving
This is the content for tab panel #1. You can replace this content with whatever you'd like inside the first panel.
Subscribe & Save
1-month supply delivered every 1 month
Free reusable container
Free 3-5 day shipping
Pause or cancel anytime
30 days risk-free
One-time purchase
1 Pack
(30 day trial serving)
Subscriptions are delivered every 30 days
Most popular!
Buy 2 Get 1 Free
(90 day serving starter Kit)
Subscriptions are delivered every 90 days
$0.42
/serving
Subscribe & Save BIG (33% OFF Forever)
FREE & Fast Shipping forever
60 day risk free guarantee
2x rewards points
Easily cancel, skip or pause anytime
Over 3,500+ Happy Subscribers
One-time purchase
Save $
FREE SHIPPING
with subscriptions
In stock, ready to ship
*We recommend 3-6 months of consistent use for best results
How does our NAD⁺ 4-in-1 work?
How does the 60 day trial work? 🗓
How does the subscription work? 🔄
Is it worth subscribing? ✅
Third-Party Tested
for Purity
Scientifically Proven
Ingredients
60-Day Money
Back Guarantee
FREE Express Delivery
WHAT WOMEN ARE SAYING
Over 2,000 women have tried it. Here's what they report.
Backed by Research, Not Rented Experts
No gimmicks, no hype. Just the cellular science behind why menopause drains more than your hormones — and a formula built around the full cascade.
Perennial is built on published studies, clinically studied ingredients, and transparent dosing. Every ingredient targets a specific stage of the NAD+ cascade that accelerates during menopause. We show you exactly what's in each capsule — and why a woman going through menopause needs all four, not just one.
Menopausal fatigue isn't a lack of motivation
It's a second system crashing.
Midlife fatigue isn’t
a lack of motivation
It’s biology.
Your NAD+ levels collapse during menopause
NAD+ is the fuel your cells need for energy, focus, and repair. Your brain uses it to think clearly. Your muscles use it to get through the day. Without enough, nothing works — no matter how much sleep you get or how clean you eat.
When NAD Runs Low:
The 2 PM wall — empty-tired, not sleepy-tired
Sitting in your car after work before walking inside
Reading the same email three times and not retaining it
Waking at 3 AM, lying there, unable to fall back asleep
But Here's The Good News…
Unlike hormones, NAD+ can be rebuilt. Your cells still have the machinery. They just need fuel.
You don't need another hormone supplement.
You don't need more adaptogens that only touch Engine One.
You don't need five bottles targeting the same hormonal cascade
You need support for Engine Two — the one nobody told you was stalling.
Perennial is the first formula built around the full menopausal NAD+ cascade. One capsule. Four ingredients. Each targeting a different stage of what's happening inside your cells right now
No stimulants.
No hormones.
No fake energy.
Just clean, research-backed cellular fuel for the engine that's been running on empty.
It fits your routine with zero effort. It works quietly underneath everything else. With consistent use, women report feeling steadier, sharper, and more like themselves — the version they thought was gone.
Both engines fueled. That's the Perennial difference.
The Core Four
4 ingredients targeting the full menopausal NAD+ cascade.
Produce it, protect it, activate it, deliver it.
Your cells use NR to produce new NAD+ — the fuel that's been disappearing since the enzyme woke up. 500mg is a clinical-strength dose, enough to meaningfully rebuild what menopause has been draining.
Trans-Resveratrol (150 mg)
The Activator
Once NAD+ is restored, Resveratrol activates the repair pathways that use it — the longevity genes (sirtuins) that repair DNA and regulate cellular aging. We use Trans-Resveratrol, the bioactive form, so your cells can actually put the fuel to work.
Quercetin (100 mg)
The Enzyme Blocker
This is the ingredient that blocks the enzyme the presell article described — the one that wakes up when estrogen drops and starts consuming your NAD+. Quercetin inhibits CD38, plugging the leak so your body can actually keep the NAD+ it makes. It also protects Resveratrol from being broken down, boosting its effectiveness.
Galactomannans (10 mg)
The Delivery System
The other three ingredients only matter if they survive digestion and reach your cells. Galactomannans are gel-forming fibers that protect the formula through your gut, ensuring NR, Quercetin, and Resveratrol actually get where they need to go. They also stabilize post-meal energy and support your microbiome.
Why All Four Matter During Menopause
Most NAD+ supplements give you one ingredient — more NAD+. But they don't block the enzyme that's consuming it. For a woman in menopause, that's like pouring water into a bucket with a hole in the bottom. Perennial addresses the full cascade:
Foundation Four addresses the entire energy system:
Produce: NR creates new NAD+.
Protect: Quercetin stops NAD+ from being destroyed or wasted.
Perform: Resveratrol activates the repair pathways that put NAD+ to work.
Balance: Galactomannans ensures all three survive digestion and reach your cells intact.
What Women Actually Feel
When Engine Two Gets Fuel Again
This isn't a stimulant. It's not an overnight miracle. Here's what women going through menopause typically report:
60 DAY
RISK FREE
TRIAL
Cellular Support for Women Going Through Menopause
The enzyme doesn't take weekends off. Neither should your cellular support. Subscribe and never run out — members save up to 66% + free shipping.
What sets Perennial apart from every other menopause supplement?
A 4-in-1 formula that targets the cellular cascade — not just the hormonal one
Convenience: 4 ingredients in 1, perfect formulation.
Transparency: 100% open label; no hidden blends.
Vitality: Targets the menopausal NAD+ cascade specifically.
Science: Ingredients backed by published research.
Defense: Added antioxidants for cellular protection
Potency: Clinically dosed for real results.
NAD+
4-in-1
Generic Menopause
Supplements
Frequently Asked Questions
What is NAD+ and why is it important?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell. It is essential for converting nutrients into energy (ATP) and supporting cellular repair. As we age, natural NAD+ levels decline, which can impact energy levels and cellular health. This supplement is designed to support those levels.
How does this formula support cellular health?
Our formula uses a multi-pronged approach. It delivers 500mg of Nicotinamide Riboside (NR), a direct precursor that the body converts into NAD+. We combine this with Trans-resveratrol and Quercetin, powerful antioxidants that support sirtuin activation (longevity genes) and fight oxidative stress.
Why are Galactomannans included in the formula?
Galactomannans (derived from Fenugreek) are included to help support the bioavailability and absorption of the nutrients, ensuring your body gets the most out of every capsule.
How and when should I take this supplement?
As a dietary supplement, take two (2) capsules once a day. For the best results, we recommend taking them 20-30 minutes before a meal with an 8 oz glass of water, or as directed by your healthcare professional.
How long before I notice a difference?
Most women report sleep improvements within the first 1-2 weeks. The afternoon energy wall typically softens around week 3-4. By month 2-3, the compounding effect is clear — steadier energy, sharper focus, and a feeling that you're actually present again.
This is why we made our guarantee is 60 days, not 30.
Is this specifically for women in menopause?
Perennial supports NAD+ levels in anyone over 35. But it's especially effective for women going through perimenopause and menopause because of how estrogen decline accelerates NAD+ loss. The enzyme (CD38) that consumes NAD+ becomes hyperactive when estrogen drops — and Perennial is the only formula that addresses the full cascade: producing NAD+, blocking the enzyme, activating repair pathways, and ensuring delivery.
What is the difference between Nicotinamide Riboside (NR) and NMN?
Both NR and NMN are precursors to NAD+. We utilize Nicotinamide Riboside (500mg) because it is a highly studied form of Vitamin B3 proven to effectively elevate NAD+ levels in the body.
Do you use any natural ingredients?
Yes. We use Trans-resveratrol sourced from Japanese Knotweed and Quercetin from the Sophora japonica flower, along with Galactomannans from Fenugreek seeds, to provide a potent, plant-derived support system for your cells.
Where is this product manufactured?
Made in the USA with global ingredients
Customer Reviews
I just feel better overall since taking this. More energy, better sleep, clearer mind. Simple as that.
This is a very effective NAD+ supplement. I notice the difference in my energy and overall well-being. Definitely recommend trying it.
No more afternoon slumps! My energy stays consistent throughout the day. This has made a huge difference in my productivity.
The mental clarity I've gained is incredible. I feel sharper and more focused. This supplement really works.
My daily energy levels have increased significantly. I'm getting more done and still have energy left at the end of the day.
How does our NAD⁺ 4-in-1 work? 🤔
We combine 500 mg of Nicotinamide Riboside (NR) with trans-resveratrol, galactomannans, and quercetin to give your cells what they lose with age.
NR helps your body restore NAD, the molecule behind energy, repair, and resilience. The rest of the formula supports your mitochondria and protects your cells from everyday stress.
Taken consistently, it’s designed to help you feel more energized, more focused, and more like yourself as the years go on.
How does the 60 day trial work? 🗓
Try Perennial daily and give it a fair shot. If you don’t feel it’s supporting your energy, clarity, or overall well-being the way you hoped, just email us within 60 days of your first delivery.
We’ll refund you on your first bottle, no hoops, no hard feelings.
How does the subscription work? 🔄
We strive to make sure you have the best subscription experience possible. This means you have complete flexibility on when you want to cancel, skip, change your order date and pause upcoming orders.
In addition, we know life can get busy so we will always send you a reminder 3 days before your next order.
Choose “Subscribe & Save” at checkout and we’ll automatically send a new bottle at every month or 3 bottles every 90 days based on the interval you selected, so you never miss a day of NAD⁺ support.
Is it worth subscribing? ✅
Consistent daily use is where the real benefits happen. Healthy NAD⁺ levels build over time, and your cells rely on steady support to maintain energy, clarity, and overall vitality. Subscribing makes it effortless to stay on track.
You get a lower price, priority on new batches, earn loyalty points and enjoy the flexibility to pause, skip, or cancel anytime from your account.
Rated 4.6/5 from 323 Reviews
Get Your Energy Back
No Jitters. No Crash.
Just Clean Balance
Clinically backed support to help you feel steady, sharp, and energized again.
Made with five proven ingredients that work with your body, not against it.
Core Four
Daily NAD+ 4-in-1
Cellular Rejuvenation
Boosts Daily Energy
Sharper Mental Focus
Cellular Repair & Recovery
60-Day Money Back Guarantee
1 Pack
(30 day serving)
$0.42
/serving
Most popular!
3 for 2
(90 day serving)
$0.42
/serving
6 Pack
(180 Strips)
$0.42
/serving
This is the content for tab panel #1. You can replace this content with whatever you'd like inside the first panel.
Subscribe & Save
1-month supply delivered every 1 month
Free reusable container
Free 3-5 day shipping
Pause or cancel anytime
30 days risk-free
One-time purchase
1 Pack
(30 day trial serving)
Subscriptions are delivered every 30 days
Most popular!
Buy 2 Get 1 Free
(90 day serving starter Kit)
Subscriptions are delivered every 90 days
$0.42
/serving
Subscribe & Save Big (33% OFF Forever)
FREE & Fast Shipping forever
60 day risk free guarantee
2x rewards points
Easily cancel, skip or pause anytime
Over 3,500+ Happy Subscribers
One-time purchase
Save $
FREE SHIPPING
with subscriptions
In stock, ready to ship
*We recommend 3-6 months of consistent use for best results
How does our NAD⁺ 5-in-1 work?
How does the 30 day trial work? 🗓
How does the subscription work? 🔄
Is it worth subscribing? ✅