How does our NAD⁺ 4-in-1 work? 🤔
We combine 500 mg of Nicotinamide Riboside (NR) with trans-resveratrol, galactomannans, and quercetin to give your cells what they lose with age.
NR helps your body restore NAD, the molecule behind energy, repair, and resilience. The rest of the formula supports your mitochondria and protects your cells from everyday stress.
Taken consistently, it’s designed to help you feel more energized, more focused, and more like yourself as the years go on.
How does the 60 day trial work? 🗓
Try Perennial daily and give it a fair shot. If you don’t feel it’s supporting your energy, clarity, or overall well-being the way you hoped, just email us within 60 days of your first delivery.
We’ll refund you on your first bottle, no hoops, no hard feelings.
How does the subscription work? 🔄
We strive to make sure you have the best subscription experience possible. This means you have complete flexibility on when you want to cancel, skip, change your order date and pause upcoming orders.
In addition, we know life can get busy so we will always send you a reminder 3 days before your next order.
Choose “Subscribe & Save” at checkout and we’ll automatically send a new bottle at every month or 3 bottles every 90 days based on the interval you selected, so you never miss a day of NAD⁺ support.
Is it worth subscribing? ✅
Consistent daily use is where the real benefits happen. Healthy NAD⁺ levels build over time, and your cells rely on steady support to maintain energy, clarity, and overall vitality. Subscribing makes it effortless to stay on track.
You get a lower price, priority on new batches, earn loyalty points and enjoy the flexibility to pause, skip, or cancel anytime from your account.
Rated 4.6/5 from 323 Reviews
Get Your Energy Back
No Jitters. No Crash.
Just Clean Balance
Clinically backed support to help you feel steady, sharp, and energized again.
Made with five proven ingredients that work with your body, not against it.
Core Four
Daily NAD+ 4-in-1
Cellular Rejuvenation
Boosts Daily Energy
Sharper Mental Focus
Cellular Repair & Recovery
60-Day Money Back Guarantee
1 Pack
(30 day serving)
$0.42
/serving
Most popular!
3 for 2
(90 day serving)
$0.42
/serving
6 Pack
(180 Strips)
$0.42
/serving
This is the content for tab panel #1. You can replace this content with whatever you'd like inside the first panel.
Subscribe & Save
1-month supply delivered every 1 month
Free reusable container
Free 3-5 day shipping
Pause or cancel anytime
30 days risk-free
One-time purchase
1 Pack
(30 day trial serving)
Subscriptions are delivered every 30 days
Most popular!
Buy 2 Get 1 Free
(90 day serving starter Kit)
Subscriptions are delivered every 90 days
$0.42
/serving
Subscribe & Save BIG (33% OFF Forever)
FREE & Fast Shipping forever
60 day risk free guarantee
2x rewards points
Easily cancel, skip or pause anytime
Over 3,500+ Happy Subscribers
One-time purchase
Save $
FREE SHIPPING
with subscriptions
In stock, ready to ship
*We recommend 3-6 months of consistent use for best results
How does our NAD⁺ 4-in-1 work?
How does the 60 day trial work? 🗓
How does the subscription work? 🔄
Is it worth subscribing? ✅
Third-Party Tested
for Purity
Scientifically Proven
Ingredients
60-Day Money
Back Guarantee
FREE Express Delivery
CUSTOMER TESTIMONIALS
Thousands of happy, energized customers.
Backed by Research, Not Rented Experts
No gimmicks, no hype. Just evidence-driven formulation and real results from real people.
Perennial is built on published studies, clinically studied ingredients, and transparent dosing, not personalities. We show you exactly what’s in each capsule, why it’s there, and how it’s meant to support your cells as they age.
Midlife fatigue isn’t a lack of motivation
It’s biology
Midlife fatigue isn’t
a lack of motivation
It’s biology.
Your NAD levels decline with age
NAD+ is a coenzyme your cells use to turn nutrients into usable energy and support key repair pathways.
Across aging research, NAD+ naturally declines over time, especially under modern stressors like poor sleep, overtraining, and chronic stress.
When NAD Runs Low:
Less all-day energy (bigger afternoon crash)
Slower recovery and feeling more “run down"
Lower mental clarity and focus
Sleep that feels less restorative
But Here's The Good News…
You can support your energy, clarity, and resilience even as NAD naturally drops with age.
You do not need complicated routines.
You do not need expensive treatments.
You do not need multiple supplements fighting the same problem.
You just need support that actually goes to the root.
Perennial NAD 4 in 1 is the simplest daily step to help your cells create and maintain the energy they depend on.
No stimulants.
No crashes.
No fake boosts.
Just clean, research backed ingredients that help your body function the way it is meant to.
It fits your routine with zero effort.
It works quietly in the background.
With consistent use you feel steadier more focused and more like yourself again.
A simple ritual that makes a real difference.
That is the Perennial promise.
The Core Four
4 clinically-aligned ingredients to restore NAD+, activate longevity genes, and fuel sustained energy.
Nicotinamide Riboside (NR) is a high-efficiency precursor that your cells use to create NAD+, the essential fuel for mitochondrial energy. We use a clinical-strength 500 mg dose to directly reverse the age-related decline of this vital molecule.
Trans-Resveratrol (150 mg)
The Activator
If NAD+ is the fuel, Resveratrol is the gas pedal. It activates Sirtuins (longevity genes) that repair DNA and regulate aging. We use Trans-Resveratrol—the bioactive form—to ensure it can effectively "turn on" these cellular repair pathways.
Quercetin (100 mg)
The Multiplier
A dual-action defender. Quercetin inhibits CD38 (an enzyme that destroys NAD+), plugging the leak in your energy tank. It also inhibits the enzymes that break down Resveratrol, significantly boosting its absorption and effectiveness in the body.
Galactomannans (10 mg)
The Balancer
A stealthy stabilizer. Galactomannans are gel-forming fibers that slow sugar absorption and smooth post-meal energy swings. Potent even at small doses, they also nourish your gut microbiome—supporting metabolic balance and steady energy from the inside out.
Why They Are Better Together
Most supplements fail because they target only one part of the cycle. Perennial addresses the entire energy system:
Foundation Four addresses the entire energy system:
Produce: NR creates new NAD+.
Protect: Quercetin stops NAD+ from being destroyed or wasted.
Perform: Resveratrol uses that energy to activate repair genes and stabilize mental focus.
Balance: Galactomannans helps absorption, regulates post-meal blood sugar and support gut health
What You’ll Actually Feel
Backed by Cellular Science
From your first dose to long-term transformation, see how consistency rewires your vitality at the cellular level.
60 DAY
RISK FREE
TRIAL
NAD+ Support for
Clean, Steady Energy
Never run out of Perennial with our subscription plans. Members get up to 66% off + free shipping.
What sets Perennial’s NAD 4-in-1 apart from ordinary supplements?
A 4-in-1 formulation crafted for convenience, consistency, and daily longevity support
Convenience: 4 ingredients in 1, perfect formulation.
Transparency: 100% open label; no hidden blends.
Vitality: Supports cellular energy & healthy aging.
Science: Ingredients backed by published research.
Defense: Added antioxidants for cellular protection
Potency: Clinically dosed for real results.
NAD+
4-in-1
Generic NAD
Supplements
Frequently Asked Questions
What is NAD+ and why is it important?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell. It is essential for converting nutrients into energy (ATP) and supporting cellular repair. As we age, natural NAD+ levels decline, which can impact energy levels and cellular health. This supplement is designed to support those levels.
How does this formula support cellular health?
Our formula uses a multi-pronged approach. It delivers 500mg of Nicotinamide Riboside (NR), a direct precursor that the body converts into NAD+. We combine this with Trans-resveratrol and Quercetin, powerful antioxidants that support sirtuin activation (longevity genes) and fight oxidative stress.
Why are Galactomannans included in the formula?
Galactomannans (derived from Fenugreek) are included to help support the bioavailability and absorption of the nutrients, ensuring your body gets the most out of every capsule.
How and when should I take this supplement?
As a dietary supplement, take two (2) capsules once a day. For the best results, we recommend taking them 20-30 minutes before a meal with an 8 oz glass of water, or as directed by your healthcare professional.
How long does it take to see results?
Everyone’s physiology is different. While NAD+ levels may begin to rise shortly after starting supplementation, most users report noticeable benefits in energy, focus, and overall well-being after 2 to 4 weeks of consistent daily use.
The most impactful effects being around 8 weeks of consistent use
Is this product suitable for everyone?
This product is formulated for healthy adults over the age of 18. If you are pregnant, nursing, or have a known medical condition, please consult your physician before adding this or any dietary supplement to your routine.
What is the difference between Nicotinamide Riboside (NR) and NMN?
Both NR and NMN are precursors to NAD+. We utilize Nicotinamide Riboside (500mg) because it is a highly studied form of Vitamin B3 proven to effectively elevate NAD+ levels in the body.
Do you use any natural ingredients?
Yes. We use Trans-resveratrol sourced from Japanese Knotweed and Quercetin from the Sophora japonica flower, along with Galactomannans from Fenugreek seeds, to provide a potent, plant-derived support system for your cells.
Where is this product manufactured?
Made in the USA with global ingredients
Customer Reviews
I just feel better overall since taking this. More energy, better sleep, clearer mind. Simple as that.
This is a very effective NAD+ supplement. I notice the difference in my energy and overall well-being. Definitely recommend trying it.
No more afternoon slumps! My energy stays consistent throughout the day. This has made a huge difference in my productivity.
The mental clarity I've gained is incredible. I feel sharper and more focused. This supplement really works.
My daily energy levels have increased significantly. I'm getting more done and still have energy left at the end of the day.
How does our NAD⁺ 4-in-1 work? 🤔
We combine 500 mg of Nicotinamide Riboside (NR) with trans-resveratrol, galactomannans, and quercetin to give your cells what they lose with age.
NR helps your body restore NAD, the molecule behind energy, repair, and resilience. The rest of the formula supports your mitochondria and protects your cells from everyday stress.
Taken consistently, it’s designed to help you feel more energized, more focused, and more like yourself as the years go on.
How does the 60 day trial work? 🗓
Try Perennial daily and give it a fair shot. If you don’t feel it’s supporting your energy, clarity, or overall well-being the way you hoped, just email us within 60 days of your first delivery.
We’ll refund you on your first bottle, no hoops, no hard feelings.
How does the subscription work? 🔄
We strive to make sure you have the best subscription experience possible. This means you have complete flexibility on when you want to cancel, skip, change your order date and pause upcoming orders.
In addition, we know life can get busy so we will always send you a reminder 3 days before your next order.
Choose “Subscribe & Save” at checkout and we’ll automatically send a new bottle at every month or 3 bottles every 90 days based on the interval you selected, so you never miss a day of NAD⁺ support.
Is it worth subscribing? ✅
Consistent daily use is where the real benefits happen. Healthy NAD⁺ levels build over time, and your cells rely on steady support to maintain energy, clarity, and overall vitality. Subscribing makes it effortless to stay on track.
You get a lower price, priority on new batches, earn loyalty points and enjoy the flexibility to pause, skip, or cancel anytime from your account.
Rated 4.6/5 from 323 Reviews
Get Your Energy Back
No Jitters. No Crash.
Just Clean Balance
Clinically backed support to help you feel steady, sharp, and energized again.
Made with five proven ingredients that work with your body, not against it.
Core Four
Daily NAD+ 4-in-1
Cellular Rejuvenation
Boosts Daily Energy
Sharper Mental Focus
Cellular Repair & Recovery
60-Day Money Back Guarantee
1 Pack
(30 day serving)
$0.42
/serving
Most popular!
3 for 2
(90 day serving)
$0.42
/serving
6 Pack
(180 Strips)
$0.42
/serving
This is the content for tab panel #1. You can replace this content with whatever you'd like inside the first panel.
Subscribe & Save
1-month supply delivered every 1 month
Free reusable container
Free 3-5 day shipping
Pause or cancel anytime
30 days risk-free
One-time purchase
1 Pack
(30 day trial serving)
Subscriptions are delivered every 30 days
Most popular!
Buy 2 Get 1 Free
(90 day serving starter Kit)
Subscriptions are delivered every 90 days
$0.42
/serving
Subscribe & Save Big (33% OFF Forever)
FREE & Fast Shipping forever
60 day risk free guarantee
2x rewards points
Easily cancel, skip or pause anytime
Over 3,500+ Happy Subscribers
One-time purchase
Save $
FREE SHIPPING
with subscriptions
In stock, ready to ship
*We recommend 3-6 months of consistent use for best results
How does our NAD⁺ 5-in-1 work?
How does the 30 day trial work? 🗓
How does the subscription work? 🔄
Is it worth subscribing? ✅